• In summary the association of CK to tubulin and

  2020-07-28

  

  In summary, the association of CK1δ to α-tubulin and various proteins involved in mitosis points to a role of CK1δ in regulating key aspects of cell division and mitotic progression and by performing Michaelis–Menten kinetics we identified α-tubulin as the preferred interaction partner of CK1 isofor

• CLICs are known to be present in intracellular

  2020-07-28

  

  CLICs are known to be present in intracellular organelles, specifically CLIC4 (also known as mtCLIC) was shown to be present in the mitochondria of keratinocytes (Fernandez-Salas et al., 2002), and CLIC1 to the nucleus of CHO-K1 cells where IAA-94 arrested these cells in G2/M phase (Valenzuela et al

• br Acknowledgment This work is supported by the German

  2020-07-27

  

  Acknowledgment This work is supported by the German Research Foundation (DFG) grant RA2717/2–1 (AYR and NF). The ubiquitin proteasome system The ubiquitin proteasome system (UPS) plays a significant role in the regulation of cell growth and survival, in addition to maintaining cellular homeos

• GLP also showed cardioprotective effects i e infarct size re

  2020-07-27

  

  GLP-1 also showed cardioprotective effects (i.e., infarct size reduction and ejection fraction improvement) in experimental models of myocardial ischemia-reperfusion injury by suppressing caspase-3 activation and preventing apoptosis of cardiomyocytes [[50], [51]]. Of note, such a cardioprotection w

• In this study cell migration in response to LTD exhibited

  2020-07-27

  

  In this study, cell migration in response to LTD4 exhibited a typical bell-shaped dose-response curve with optimal activity at 10 nM. However, the effect of inhaled CysLTs on airway inflammatory cells in vivo has not been widely reported to date, therefore, the role of CysLTs in the development of a

• Cytochromes P CYP are a superfamily of hemoproteins

  2020-07-27

  

  Cytochromes P450 (CYP 450) are a superfamily of hemoproteins containing a heme cofactor, which are widely distributed in animals, plants and microbes (Hannemann et al., 2007). CYP450 exhibits a variety of biological functions including biotransformation of drugs, detoxification of endogenous and xen

• In humans CYP A major isoforms of CYP As in

  2020-07-27

  

  In humans, CYP3A4/5, major isoforms of CYP3As in the liver, have variants that reduce the enzyme activities [33], [34]. In addition, Werk et al. recently reported the first case of a complete failure of CYP3A enzyme activity due to homozygous loss-of-function mutation of CYP3A4 combined with nonfunc

• Cyclin dependent kinases CDKs are serine threonine

  2020-07-27

  

  Cyclin-dependent kinases (CDKs) are serine/threonine kinase proteins comprising of 20 members that fall under protein kinases family. These enzymes play a crucial role in cell division, transcription and post-transcriptional modification [7]. For example, the formation of an active complex composed

• br Materials and methods br Results br Discussion Herein

  2020-07-27

  

  Materials and methods Results Discussion Herein we report the expression of shrimp Cdk-2 in hepatopancreas, gills and muscle, finding higher expression in hepatopancreas and gills and lower expression in muscle. No significant changes due to hypoxia and hypoxia reoxygenation were detected o

• Fmoc-Gly-OPfp Forskolin is a labdane diterpene

  2020-07-27

  

  Forskolin is a labdane diterpene produced from the root of Coleus forskohlii (Bhat et al., 1977). Its extract has been recorded in Ayurveda medicine since ancient times and its medicinal value has been studied since early-1980s (Bristow et al., 1984; Kavitha et al., 2010). Early studies have suggest

• Our data show a site specific interaction of DDR with

  2020-07-25

  

  Our data show a site-specific interaction of DDR2 with collagen II. This indicates that the DDRs recognise a particular sequence within collagen and not simply the collagenous triple helix per se. This common tertiary structure of all collagens is formed by three α chains, each with a repeating G-X-

• 98059 Epigenetic silencing of genes that determine tumor inv

  2020-07-25

  

  Epigenetic silencing of genes that determine tumor invasiveness, growth patterns of tumors, and tumor-cell apoptosis12, 29 may also affect the expression of drug-metabolizing enzymes, thereby providing an additional genetic mechanism in pharmacogenomics. Trisomy 8 that contains wild-type GGH could b

• Accurate equilibrium predictions of CO

  2020-07-25

  

  Accurate equilibrium predictions of CO2 containing mixtures, however, are challenging with traditional equations of state. The reason for this may be that CO2 has a large quadrupole moment. The large quadrupole moment of CO2, as well as size asymmetry, are for instance believed to be the reasons for

• This study demonstrates that GUL

  2020-07-25

  

  This study demonstrates that GUL-1 affects multiple pathways/processes. As GUL-1 is likely to function as an RNA-binding protein, it is conceivable that the mRNAs involved are bound to GUL-1 as part of the regulatory function of the protein. In fact, in S. cerevisiae Ssd1 was shown to bind multiple

• Herein we further established a

  2020-07-25

  

  Herein, we further established a dynamic DNA self-assembly activated hemin-mimetic enzymes system by embedding DNA-hemin into an entropy-driven DNA-assembly for fluorescent biosensing. The entropy-driven dynamic DNA-assembly is one of the toehold-mediated isothermal strand displacement reactions, wh

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