• In SLO permeabilized human sperm the AR elicited

  2019-09-10

  

  In SLO-permeabilized human sperm, the AR elicited by calcium, persistently active Arf6 [41] and Rab3A, 8-pCPT-2′-O-Me-cAMP [8], diacylglycerol and a non-hydrolyzable analog [35], is sensitive to the PLC blocker U73122. Furthermore, 8-pCPT-2′-O-Me-cAMP elicits a calcium signal in non-permeabilized sp

• Results are expressed as mean s

  2019-09-10

  

  Results are expressed as mean±s.e.m. Paired or unpaired Student\'s t test was used for comparisons between 2 groups and one-way ANOVA followed by Bonferroni\'s post-test for more groups. Statistical significance was assigned if p Results and discussion Variations in [Ca2+]i in cardiomyocytes loade

• According to the Nomenclature Committee of the International

  2019-09-10

  

  According to the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (NC-IUBMB, 1992), peptidases are divided into two classes, namely exopeptidases and endopeptidases, based on their actions on substrates and their active sites, respectively. Endopeptidases inclu

• Brilliant Blue G and For statistical analysis the Statistica

  2019-09-10

  

  For statistical analysis, the Statistical Package for Social Sciences (SPSS) was used (version 21.0; SPSSInc., Chicago, IL). Chi-square (x2) exact test was used for the comparison of categorical data, whereas Wilcoxon and Mann–Whitney U tests were used for the analysis of nonparametric variables bas

• br RING type E s

  2019-09-10

  

  RING-type E3s and their substrates There is enormous diversity in substrate ubiquitination and its regulation, as the targets of RING-type E3s are incredibly varied. RING-type E3s are implicated as tumor suppressors, oncogenes, and mediators of endocytosis, and play critical roles in complex mult

• It is well known that Doxorubicin induced cardiotoxicity occ

  2019-09-09

  

  It is well known that Doxorubicin-induced cardiotoxicity occurs via p53-mediated apoptosis (Lorusso et al., 2007). However, there are few studies elucidating the mechanism of HFS induced by PLD. We found that PLD induces keratinocyte apoptosis in a very low dose, and the damage induced by PLD cannot

• In patients with CTEPH ET levels are raised and have

  2019-09-09

  

  In patients with CTEPH, ET-1 levels are raised and have been shown to fall after PEA surgery [24]. After an acute pulmonary embolism there is obstruction of the pulmonary Alisol A and by acute thrombus and elevated levels of ET-1 [28], [30]. Elevated levels of ET-1 have also been observed in air emb

• When women reach the menopause they experience a number of

  2019-09-09

  

  When women reach the menopause they experience a number of physical complaints such as hot flushes, vaginal dryness and mood changes [1]. Bone loss also becomes manifest at this time [1], [2], but women will often not suffer from back pain before a vertebral fracture occurs. Women who have had one f

• Tropical theileriosis is caused by the

  2019-09-09

  

  Tropical theileriosis is caused by the apicomplexan parasite Theileria annulata which is transmitted by a tick vector from the genus Hyalomma in cattle (Echebli et al., 2014, Li et al., 2014). Theileria parasites invade the leukocytes by sporozoites secreted from the vector, schizonts mature into me

• During the course of enzymatic digestion protein is digested

  2019-09-09

  

  During the course of enzymatic digestion, protein is digested into large peptides and these large peptides are then further digested into small fragments. αs1-Casein f15–39, which contains 25 amino Imipenem residues was the longest iTRAQ-labelled peptide identified in the samples digested with GE at

• EPZ031686 A factor that complicates the use

  2019-09-09

  

  A factor that complicates the use of human liver EPZ031686 is one of variability, which arises in part because many of the human liver samples available for research show various stages of a variety of disease states (steatosis (fatty liver), cirrhosis, carcinogenesis in adjacent tissue), although

• To further confirm the roles of the CYP

  2019-09-09

  

  To further confirm the roles of the CYP450 enzymes involved in the metabolism of Dip in rat liver microsomes, we utilized not only chemical inhibitors but also a correlation analysis and a panel of recombinant rat CYP450 enzymes to evaluate the contribution of CYP450 enzymes. The results of the corr

• br Concluding Remarks Recent studies

  2019-09-09

  

  Concluding Remarks Recent studies have provided unprecedented details of APC/C structure and enzymology, which explain how the activity of this massive E3 ligase is controlled, and how ubiquitylation is achieved to temporally regulate cell division. Although one pervasive question has been why th

• br Materials and methods br Results and discussion

  2019-09-09

  

  Materials and methods Results and discussion Conflict of interest Acknowledgments This work was supported by grants from National 973 Project (2015CB755700) and the Doctoral Starting up Foundation of Henan University of Science and Technology (13480033). Introduction Progression thro

• It was hypothesized that if modafinil acts primarily via

  2019-09-09

  

  It was hypothesized that if modafinil acts primarily via a noradrenergic mechanism, Dbh −/− mice should be non-responsive since they completely lack NE. In contrast, if modafinil acts mainly through DA systems, these mice should be hypersensitive. Modafinil was tested in Dbh −/− mice using both loco

11109 records 663/741 page Previous Next First page 上5页 661662663664665 下5页 Last page