• At this point it needs however to

  2021-12-17

  

  At this point it needs, however, to be mentioned that most in vivo studies regarding the herein discussed nuclear receptors were performed in rodents, especially in mice. Due to the significant differences in metabolism in mice and humans, not all results are translatable between these species and h

• Together the epigenetic interplay revealed in

  2021-12-17

  

  Together, the epigenetic interplay revealed in this study enabled us to expand the therapeutic potential of EZH2is from hematological malignances to solid tumors. In solid tumors, EZH2i-driven transcriptional changes are shown to be dispensable of H3K27me-regulated transcriptional network. Instead,

• Myelination by oligodendrocytes is required for

  2021-12-17

  

  Myelination by oligodendrocytes is required for saltatory nerve impulse conduction and proper CNS function (Bercury and Macklin, 2015). Defects in myelination and remyelination impair saltatory nerve conduction and functional connectivity leading to cognitive, behavioral, and motor deficits in neuro

• br Materials and methods br Results br Discussion Type I

  2021-12-17

  

  Materials and methods Results Discussion Type I ECa is associated with estrogen excess, obesity and hormone-receptor positivity. However, the function of ERα on ECa is considered complicated. The expression of ERα is reduced in grade III ECa clinical samples [13]. The high ERα expression is

• The mechanistic basis of a

  2021-12-17

  

  The mechanistic basis of a PAE-induced reduction in HDC isoform expression is unclear at present. These reductions may be a consequence of reduced histaminergic innervation of PAE-affected brain regions. Given that these three brain regions are anatomically more distant from the ventral hypothalamus

• CONUT score is an effective detector of predicting OS

  2021-12-17

  

  CONUT score is an effective detector of predicting OS and RFS in HCC patients. We found that patients with a damaged immune-nutrition status had significantly poor OS and RFS. Our initial literature review also retrieved other studies evaluating the survival of HCC patients using CONUT score [36,48

• The eel and perhaps other euryhaline teleost fish

  2021-12-17

  

  The eel, and perhaps other euryhaline teleost fish, have the additional peptide, renoguanylin that exhibits high levels of expression within the kidney as well as the intestine. In terms of overall sequence, pre-prorenoguanylin is more homologous to pre-proguanylin than pre-prouroguanylin and a phen

• br Materials and methods br

  2021-12-17

  

  Materials and methods Results Discussion Directly modulating specific target proteins and signaling pathways with small-molecule drugs or agonistic 5,8,11-Eicosatriynoic Acid australia is widely used for cancer metastasis therapies [[39], [40], [41]]. ANXA7 acts as a metastasis suppressor

• To investigate the simultaneous effects of possible confound

  2021-12-17

  

  To investigate the simultaneous effects of possible confounding factors in the urinary 1-OHP excretion, multivariate regression analysis was performed (Table 3). Based on stepwise regression analysis, four independent variables (age, CYP1A1⁎4, GSTM1 and GSTP1 polymorphisms) entered into the final mo

• Accumulating studies revealed a decline of TET expression in

  2021-12-17

  

  Accumulating studies revealed a decline of TET1 expression in various cancers including breast, liver, colon, skin, prostate cancers [[36], [37], [38]]. Contrast to these studies, our previous research shows that TET1 is overexpressed in EC and improves the efficacy of chemotherapy in EC, coincide w

• salinomycin br Conflict of interest br Funding br Acknowledg

  2021-12-17

  

  Conflict of interest Funding Acknowledgements Introduction to SLC6 transporters The solute carrier (SLC) 6 family of membrane proteins perform the Na+-coupled symport of amino acids and amino salinomycin derivatives into cells throughout the body. Disrupting neurotransmitter SLC6-mediate

• In this study for the first time the

  2021-12-17

  

  In this study, for the first time: 1) the electrochemical glutamate oxidase-based biosensor was optimized for the determination of low micromolar glutamate concentrations; 2) the algorithm of the analysis of exocytotic and transporter–mediated glutamate release was developed; 3) the comparative anal

• It is widely acknowledged that a significant gap exists

  2021-12-17

  

  It is widely acknowledged that a significant gap exists between the increasingly detailed knowledge of subcellular mechanisms and the ability to control large-scale anatomy. Radical advances in regenerative medicine require approaches aimed at taming the fundamental complexity of cellular regulation

• Most of the tumors showed relatively higher

  2021-12-17

  

  Most of the tumors showed relatively higher GalR1 mRNA levels than the controls (Fig. 1a, Table 3). However one patient with the lower GalR1 mRNA levels (#12) had, in fact, relatively lower levels of transcript for galanin and the other galanin receptors. Patient #10 and 4 who were also expressing

• br Conclusions br Introduction Bioinformatics analysis shows

  2021-12-16

  

  Conclusions Introduction Bioinformatics analysis shows that there are about 300,000 G-rich sequences in human genome if searching with the consensus sequence (G3+N1-7G3+N1-7G3+N1-7G3+) [1], and their localizations are non-random. These G-rich sequences always localize in functional regions, su

15184 records 494/1013 page Previous Next First page 上5页 491492493494495 下5页 Last page