• Atypically BcALDH has a minor reducing activity for all

  2023-11-16

  

  Atypically, BcALDH has a minor reducing activity for all-trans-retinal, which requires the binding of the reduced form of the NADP+ (NADPH) cofactor that is a side-product of the canonical oxidation activity of BcALDH. The reduction activity that converts all-trans-retinal to all-trans-retinol was r

• In glaucoma the primary retinal defect appears

  2023-11-16

  

  In glaucoma, the primary retinal defect appears in the GCL, whereas the other retinal layers appear normal (Kendell et al., 1995). In the current work, chronic elevation of IOP induced RGC apoptosis, especially in the GCL, and α2 adrenergic treatment reduced RGC apoptosis. Various studies have repor

• Ketogenic diets are more effective in promoting

  2023-11-16

  

  Ketogenic diets are more effective in promoting weight loss than conventional caloric restriction [26] however, their effect on hepatic glucose and lipid metabolism remains inconclusive. Blood glucose homeostasis is tightly regulated. In both mice and humans consuming KD, baseline blood glucose decr

• br Materials and Methods br Results br

  2023-11-16

  

  Materials and Methods Results Discussion Voluminous literature is available describing the regulation of ras inhibitor homeostasis by central and peripheral mechanisms in poultry [35,36]. However, the neuroendocrine mechanism(s) of photoperiod induced hypothalamic regulation of food intake

• AMPK modulates changes in lipid metabolism via the

  2023-11-16

  

  AMPK modulates changes in lipid metabolism via the regulation of fatty NSC 319726 oxidation and cholesterol synthesis in the liver. The key enzymes involved include ACC and HMGCR [27,28]. Both participate in the rate-limiting steps of fatty acids and cholesterol synthesis and are inactivated on pho

• Since the introduction of zebrafish into the

  2023-11-16

  

  Since the introduction of zebrafish into the laboratory, many milestones have been achieved that firmly establish this organism as a prominent genetic model for biology and medicine. Many features make this species an organism of easy maintenance in laboratory which provides advantages to understand

• We have expressed the ECDs of the

  2023-11-16

  

  We have expressed the ECDs of the human α1, β1, γ and ɛ AChR subunits in the past using the methylotropic yeast Pichia pastoris as soluble glycosylated proteins [15], [16]. Further work with the γ subunit ECD revealed a marked improvement of the solubility and yield following the mutation of hydroph

• ACh induced changes in respiratory frequency could be of

  2023-11-16

  

  ACh-induced changes in respiratory frequency could be of interest. They may reveal an important mechanism of respiratory modulation at the caudal NTS level. ACh-induced increases in respiratory frequency within this region have been also reported by Furuya et al. (2014). Changes in respiratory timin

• Whereas more research is needed to identify

  2023-11-16

  

  Whereas more research is needed to identify the precise mechanism by which FIN exerts its antidyskinetic effect, the Primaquine Diphosphate that it can negatively modulate dopaminergic transmission is also supported by our previous findings. Indeed, we have previously shown that FIN completely reve

• In earlier experiments on snails a behavioral

  2023-11-15

  

  In earlier experiments on snails, a behavioral model was employed of certain food rejection to study the mechanisms of the reconsolidation of long-term associative memory. It was found that conditioned food stimuli (reminder) presentation, combined with injections of NMDA glutamate receptor antagoni

• Aurora A overexpression is also related to

  2023-11-15

  

  Aurora-A overexpression is also related to the activation of NF-κB, a potent anti-apoptotic effector that may play a role in preventing apoptosis in cancer 8-pCPT-2-O-Me-cAMP-AM [18]. These data show that we are still at the beginning of unraveling the complex mechanism by which these gene product

• CK is considered a central

  2023-11-15

  

  CK is considered a central controller of cellular energy homeostasis that catalyzes the reversible transfer of a phosphoryl group from ATP to adenosine diphosphate (ADP) and creatine to produce PCr [5]. This enzyme builds up a large pool of rapidly diffusing PCr for temporal and spatial buffering of

• br Experimental section br Competing interests br Author

  2023-11-15

  

  Experimental section Competing interests Author's contributions Acknowledgement This research is partially supported by a seed fund for the Center for Drug Discovery and Translational Research (LS) and a research grant by Fujifilm (VPS and LS). The Sponsors played no roles in study desig

• br Acknowledgment Supported in part

  2023-11-15

  

  Acknowledgment Supported in part by NIH1R21EB012707 (Biegon, Anat PI). Introduction Estrogens exert pleiotropic effects on a variety of morphological, physiological and behavioral responses in all vertebrate classes ranging from fishes to mammals. Effects of estrogens in the ptc chemical conc

• Knowledge about adipose tissue has evolved considerably over

  2023-11-15

  

  Knowledge about adipose tissue has evolved considerably over the last two decades. Always been described as an inert tissue having the function of stocking lipids, adipose tissue is now recognized as a real organ with both metabolic and endocrine functions secreting various factors into the blood to

14585 records 185/973 page Previous Next First page 上5页 181182183184185 下5页 Last page